三苯基氧化膦
化学
溶解度
三苯基膦
溶剂
过滤(数学)
维蒂希反应
大小排阻色谱法
有机化学
氧化物
无机化学
色谱法
作者
Yasinalli Tamboli,Bharat B Kashid,Ram Prasad Yadav,Mohammad Rafeeq,Ravindra Yeole,Arvind Y Merwade
出处
期刊:ACS omega
[American Chemical Society]
日期:2021-05-19
卷期号:6 (21): 13940-13945
被引量:2
标识
DOI:10.1021/acsomega.1c01996
摘要
Here, a large-scale feasible, chromatography-free process to purge triphenylphosphine oxide (TPPO) from the crude product of Mitsunobu and Wittig reactions has been developed. Divergence in physicochemical properties like polarity and solubility of TPPO against the product was utilized to precipitate TPPO directly from the reaction mixture and eliminate by simple filtration on a kilogram scale at a pilot plant with high purity of the product.
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