危险系数
单核苷酸多态性
CYP1B1型
结直肠癌
基因型
内科学
肿瘤科
GSTP1公司
医学
比例危险模型
生物
胃肠病学
置信区间
遗传学
癌症
内分泌学
细胞色素P450
基因
新陈代谢
作者
Abram Bunya Kamiza,Jeng‐Fu You,Wen Chang Wang,Reiping Tang,Chun Yu Chang,Huei Tzu Chien,Chih Hsiung Lai,Li Ling Chiu,Tsai Ping Lo,Kuan Yi Hung,Chao A. Hsiung,Chih Ching Yeh
摘要
Cytochrome P450 ( CYP ), glutathione‐S‐transferase ( GST ), and N‐acetyltransferase ( NAT ) are crucial for metabolism and clearance of xenobiotics. This study investigated whether CYP , GST , and NAT single nucleotide polymorphisms (SNPs) are associated with colorectal cancer (CRC) in patients with Lynch syndrome. The interaction between these SNPs and cigarette smoking or meat consumption was also explored. We identified 270 patients with Lynch syndrome from the Taiwan Hereditary Nonpolyposis Colorectal Cancer Consortium. A weighted Cox proportional hazard model was used to calculate the hazard ratios (HRs) and 95% confidence interval (CIs). The GSTA1 rs3957356 TT (HR = 5.36, 95% CI = 2.39–12.0) and CYP1B1 rs1056836 CC (HR = 7.24, 95% CI = 3.51–14.9) were significantly associated with CRC risk when compared to wild‐type CC and GG genotypes, respectively. However, the CYP1A1 rs4646903 CC genotype significantly reduced the risk of CRC (HR = 0.33, 95% CI = 0.12–0.89) when compared to TT genotype. Moreover, significant interactions were observed between NAT1 acetylation and CYP1B1 rs1056827 and meat consumption.Our results suggest that xenobiotic‐metabolizing SNPs are not only associated with CRC risk in patients with Lynch syndrome in Taiwan but also interact with meat consumption to modify the disease risk. Environ. Mol. Mutagen. 59:69–78, 2018. © 2017 Wiley Periodicals, Inc.
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