Fabrication of capsaicin functionalized reduced graphene oxide and its effect on proliferation and differentiation of osteoblasts

Herein, we report a new simple and biological approach for the preparation of capsaicin adsorbed reduced graphene oxide (RGO), where capsaicin acts as a stabilizing and deoxygenating agent. The capsaicin that is decorated on graphene surface plays an important role as a capping agent to avoid the aggregation of graphene sheets. The capsaicin functionalized RGO stimulated the differentiation and proliferation of osteoblasts to a larger extent, which is a significant feature for the use of biomaterials in biomedical application such as in bone tissue engineering, more speciafically in the case of diseases such as osteoporosis.