肌钙蛋白
自噬
基因敲除
细胞生物学
癌症研究
下调和上调
抄写(语言学)
转录因子
生物
化学
细胞凋亡
心肌梗塞
血清反应因子
医学
内科学
生物化学
基因
语言学
哲学
作者
Cuiyun Liu,Yuhui Zhang,Rui-Bei Li,Zhou Luyu,Tao An,Rongcheng Zhang,Mei Zhai,Yan Huang,Kao Wen Yan,Yanhan Dong,Murugavel Ponnusamy,Chan Shan,Sheng Xu,Qi Wang,Yanhui Zhang,Jian Zhang,Kun Wang
标识
DOI:10.1038/s41467-017-02280-y
摘要
Abstract Increasing evidence suggests that long noncoding RNAs (lncRNAs) play crucial roles in various biological processes. However, little is known about the effects of lncRNAs on autophagy. Here we report that a lncRNA, termed cardiac autophagy inhibitory factor (CAIF), suppresses cardiac autophagy and attenuates myocardial infarction by targeting p53-mediated myocardin transcription. Myocardin expression is upregulated upon H 2 O 2 and ischemia/reperfusion, and knockdown of myocardin inhibits autophagy and attenuates myocardial infarction. p53 regulates cardiomyocytes autophagy and myocardial ischemia/reperfusion injury by regulating myocardin expression. CAIF directly binds to p53 protein and blocks p53-mediated myocardin transcription, which results in the decrease of myocardin expression. Collectively, our data reveal a novel CAIF-p53-myocardin axis as a critical regulator in cardiomyocyte autophagy, which will be potential therapeutic targets in treatment of defective autophagy-associated cardiovascular diseases.
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