纳米医学
药物输送
医学
纳米技术
毒品携带者
癌症
药品
纳米颗粒
癌症治疗
药理学
材料科学
内科学
作者
Andrew Z. Wang,Robert Langer,Omid C. Farokhzad
出处
期刊:Annual Review of Medicine
[Annual Reviews]
日期:2012-02-18
卷期号:63 (1): 185-198
被引量:1343
标识
DOI:10.1146/annurev-med-040210-162544
摘要
Nanomedicine, the application of nanotechnology to medicine, enabled the development of nanoparticle therapeutic carriers. These drug carriers are passively targeted to tumors through the enhanced permeability and retention effect, so they are ideally suited for the delivery of chemotherapeutics in cancer treatment. Indeed, advances in nanomedicine have rapidly translated into clinical practice. To date, there are five clinically approved nanoparticle chemotherapeutics for cancer and many more under clinical investigation. In this review, we discuss the various nanoparticle drug delivery platforms and the important concepts involved in nanoparticle drug delivery. We also review the clinical data on the approved nanoparticle therapeutics as well as the nanotherapeutics under clinical investigation.
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