Synthesis of 1-substituted-4-[4-(1H-indol-3-yl)butyl]piperazines

A convenient synthetic route for preparation of various 4-[4-(1H-indol-3-yl)butyl]piperazines bearing heterocyclic and aliphatic substituents in position 1 has been developed.During this work some synthetic possibilities of common precursor, 4-[4-(1H-indol-3-yl)butyl]piperazine, were studied and evaluated.