Objective To compare the comfort and effect of two oxygen therapies through low-flow nasal cannula.Methods 150 patients receiving low-flow oxygen therapy were randomly divided into control group(n=78) and observation group(n=72).In observation group,patients received nonhumidified oxygen therapy,while in control group,patients received humidified oxygen therapy.The comfort of patients and effect of the therapy in the 3rd and 5th day of the therapy were compared.Results There was no significant difference of the comfort and effect between patients receiving nonhumidified and humidified oxygen therapy.Conclusion Nonhumidified oxygen therapy exerts no influence on the comfort and effect of low-flow oxygen therapy by nasal cannula and it can prevent hospital-acquired infection.