P16 expression in hypertrophic scars and its significance

Objective To observe the hypertrophic scar fibroblasts P16 expression,and to explore the differences between normal skin tissue correlation. Methods The experimental group hypertrophic scar and normal skin tissue as a control group,two groups of P16 expression was detected by SP immunohistochemistry. Results P16 positive expression rate in hypertrophic scars 78.9%,significantly higher than that in the control group(P0.05).No significant gender expression site. Conclusions The scar formation process,P16 as a negative regulator of cell cycle expression imbalance important mechanism involved in scar outcome.