Diffusion tensor imaging(DTI) is a novel,sensitive,and quantified technique to detect the diffusion feature of water molecule.In this paper,we reviewed the basic principle and parameters of DTI,the processing methods of DTI data,and the different changes of parameters of DTI with the neonatal brain white matter and gray matter.It showed that parameters of DTI changed regularly with development of premature and neonatal brain white matter,and DTI is helpful to evaluate the development of brain white matter quantitatively.