Progress on the nor-oleanane triterpenoids

Objective To study the nor-oleanane triterpenoids and search the lead compounds to determine its specific bioavailability.Methods According to the related literatures of nor-oleanane triterpenoids and the investigation of our team,the characters of nor-oleanane triterpenoids were illustrated.Results All kinds of the aglycones of the nor-oleanane triterpenoids were analyzed,and their distribution in nature,pharmacological activity,structural diversity and the rules of spectrosocopy were summarized.The biosynthesis pathway of the 28-nor-oleanane triterpene saponins with double bond at C20(29) was introduced.Conclusions This article evaluates the nor-oleanane triterpenoids comprehensively,and provides the reference for searching the lead compounds with bioavailability.