医学
类风湿性关节炎
炎症
疾病
关节炎
慢性疼痛
动物研究
生物信息学
物理疗法
免疫学
病理
内科学
生物
作者
Duygu B. Baş,Jie Su,Gustaf Wigerblad,Camilla I. Svensson
出处
期刊:Pain management
[Future Medicine]
日期:2016-05-01
卷期号:6 (3): 265-284
被引量:50
摘要
Pain is one of the most challenging symptoms for patients with rheumatoid arthritis (RA). RA-related pain is frequently considered to be solely a consequence of inflammation in the joints; however, recent studies show that multiple mechanisms are involved. Indeed, RA pain may start even before the disease manifests, and frequently does not correlate with the degree of inflammation or pharmacological management. In this aspect, animal studies have the potential to provide new insights into the pathology that initiate and maintain pain in RA. The focus of this review is to describe the most commonly used animal models for studies of RA pathology, which have also been utilized in pain research, and to summarize findings providing potential clues to the mechanisms involved in the regulation of RA-induced pain.
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