Research Progress of Nanog Gene

Nanog gene is a new transcription factor reported in 2003 to be expressed in blastular inner cell mass,primitive germ cells and embryonic stem cells.Nanog plays a crucial role in the maintenance of self-renewal and pluripotency of embryonic stem cells.The research of Nanog is of great significance for developmental biology,regenerative medicine,and development of new drugs.Recently,Nanog gene has been extensively studied for its expression and mechanism of action in embryonic stem cells,somatic cells,and tumor cells.The regulation of Nanog gene is predicted to be associated with the occurrence and progress of cancer,as a promising target for prospective tumor treatment.The further investigation into the expression and regulation mechanism of Nanog gene helps to explore the novel preventive and therapeutic regimens of cancer.