Data of patients infected imipenem-resistant Acinetobacter baumannii were get from the HIS system,results of bacterial culture,susceptibility test,patients' general information and treatment effects were analyzed.From January of 2008 to December of 2010,427 strains of Acinetobacter baumannii were detected in patients,among them there were 234 imipenem-resistant strains.There was a yearly increasing trend,which was especially remarkable in 2010.Among the 234 patients infected imipenem-resistant Acinetobacter baumannii,10 died,72 were not healed and 15 gave up treatment.It can concluded that infection of imipenem-resistant Acinetobacter baumannii is with high mortality and poor effect of treatment,antimicrobial drug must be rationally used so as to delay the resistance of antibiotics.