Objective:To investigate clinical result of hypodermal injection of insulin by two different syringes on diabetic mellitus(DM)nephropathy patients.Method:43 DM nephropathy patients who used to received insulin injection by 1ml traditional syringe now by specially made syringe for DM.Result:This specially made syringe can alleviate injection pain,avoid over use of insulin,easy to spread and easy for preserve.Conclusion:Application of specially made insulin syringe can improve therapeutic result.