纳米棒
纳米壳
癌细胞
牛血清白蛋白
细胞
癌症
活力测定
化学
纳米技术
微球
生物物理学
材料科学
医学
生物
生物化学
纳米颗粒
内科学
化学工程
工程类
作者
Yuhai Guo,Wenxuan Yang,Guangjin Pu,Chunjiao Zhu,Yifan Zhu,Ji Li,Yuqiao Huang,Bo Wang,Maoquan Chu
标识
DOI:10.1186/s12951-022-01521-7
摘要
The magneto-mechanical force killing cancer cells is an interesting and important strategy for cancer therapy.Novel magnetic microspheres composed of a Fe3O4 nanocore, a bovine serum albumin (BSA) matrix, and a rod-like SiO2 nanoshell, which had flagellum-like surface for force-mediated cancer therapy were developed. One such magnetic microsphere (Fe3O4/BSA/rSiO2) at a cancer cell (not leave the cell surface) under a low frequency vibrating magnetic field (VMF) could generate 6.17 pN force. Interestingly, this force could induce cancer cell to generate reactive oxygen species (ROS). The force and force-induced ROS could kill cancer cells. The cell killing efficiency of Fe3O4/BSA/rSiO2 exposed to a VMF was enhanced with increasing silica nanorod length, and the microspheres with straight nanorods exhibited stronger cell killing ability than those with curled nanorods. Fe3O4/BSA/rSiO2 triggered by a VMF could efficiently inhibit mouse tumor growth, while these microspheres without a VMF had no significant effect on the cell cycle distribution, cell viability, tumor growth, and mouse health.These microspheres with unique morphological characteristics under VMF have great potential that can provide a new platform for treating solid tumors at superficial positions whether with hypoxia regions or multidrug resistance.
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