结直肠癌
疾病
转移
医学
癌症
肿瘤科
肿瘤微环境
表型
肿瘤异质性
癌症的病因
癌症研究
内科学
免疫学
生物
基因
遗传学
作者
Phimmada Hatthakarnkul,Jean A. Quinn,Aula Ammar,Gerard Lynch,Hester van Wyk,Donald C. McMillan,Chanitra Thuwajit,Joanne Edwards
出处
期刊:Clinical Science
[Portland Press]
日期:2022-04-01
卷期号:136 (8): 521-535
被引量:4
摘要
Colorectal cancer (CRC) is the third most common cancer worldwide. Poor survival of CRC associated with the development of tumour metastasis led to the investigation of the potential biomarkers to predict outcomes in CRC patients. Tumour budding (TB) is a well-known independent prognostic marker for poor survival and disease metastasis. Therefore, it has been suggested that TB status is included in routine clinicopathological factors for risk assessment in CRC. In contrast with a vast majority of studies regarding the prognostic power of TB, there is no clear evidence pertaining to the underlying molecular mechanism driving this phenotype, or an understanding of TB relationship with the tumour microenvironment (TME). The aim of the present study is to present a comprehensive review of TB and tumour cell signalling pathways together with the cross-talk of immune cells that could drive TB formation in CRC.
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