Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo

(Mol Ther. 28, 1600–1613; July 8, 2020) In the originally published version of this article, Edmund K. Moon was omitted from the list of authors. His name has been added to author list. The authors regret this error. Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In VivoRichman et al.Molecular TherapyJune 10, 2020In BriefTo enable remote control over CAR T cell activity, Richman et al. incorporated a ligand-induced degradation (LID) domain into the CAR. This system created a reversible off switch, depending on the presence or absence of a small molecule ligand, permitting CAR T cell regulation in vitro and in vivo. Full-Text PDF Open Archive