羟醛反应
氧离子
立体中心
化学
级联反应
立体化学
插入反应
组合化学
全合成
对映选择合成
有机化学
催化作用
离子
作者
Jiawen Lang,Siyuan Wang,Changli He,Xiaohua Liu,Xiaoming Feng
出处
期刊:Chemical Science
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:13 (4): 1163-1168
被引量:3
摘要
An efficient asymmetric synthesis of isochromanone derivatives was realized through Z-selective-1,3-OH insertion/aldol cyclization reaction involving acyclic carboxylic oxonium ylides. The combination of achiral dirhodium salts and chiral N,N'-dioxide-metal complexes, along with the use of α-diazoketones instead of α-diazoesters, enables the cascade reaction efficiently. A variety of benzo-fused δ-lactones bearing vicinal quaternary stereocenters were obtained with good to excellent enantioselectivity, bypassing the competitive 1,1-OH insertion and racemic background aldol reaction.
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