化学
空泡化
细胞质
细胞凋亡
细胞培养
作用机理
程序性细胞死亡
微管
细胞生长
细胞生物学
细胞
链霉菌
生物化学
细菌
体外
生物
遗传学
内分泌学
作者
Marilia Barreca,Miriam Buttacavoli,Gianluca Di Cara,Cesare D’Amico,Emanuela Peri,Virginia Spanò,Giovanna Li Petri,Paola Barraja,Maria Valeria Raimondi,Patrizia Cancemi,Alessandra Montalbano
标识
DOI:10.1016/j.ejmech.2023.115339
摘要
Pyrrolomycins (PMs) are a family of naturally occurring antibiotic agents, isolated from the fermentation broth of Actinosporangium and Streptomyces species. Pursuing our studies on pyrrolomycins, we performed the total synthesis of the F-series pyrrolomycins (1-4) by microwave-assisted synthesis (MAOS), thus obtaining the title compounds in excellent yields (63-69%). Considering that there is no evidence so far of the anticancer effect of this class of compounds, we investigated PMs for their antiproliferative activity against HCT116 and MCF-7 cancer cell lines. PMs showed anticancer activity at submicromolar level with a minimal effect on normal epithelial cell line (hTERT RPE-1), and they were able to induce several morphological changes including elongated cells, cytoplasm vacuolization, long and thin filopodia as well as the appearance of tunneling nanotubes (TNTs). These data suggest that PMs could act by impairing the cell membranes and the cytoskeleton organization, with subsequent increase of ROS generation and the activation of different forms of non-apoptotic cell death.
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