急性肾损伤
材料科学
活性氧
纳米技术
磁共振成像
体内
医学
细胞生物学
内科学
生物
放射科
生物技术
作者
Menglin Wu,Li Lü,Jiang Li,Qi Guo,Wang Daohan,Yue Gong,Xinhong Wu,Xue Zhao,Xuening Zhang,Yang Zhao,Xue Li
标识
DOI:10.1002/adfm.202301664
摘要
Abstract Targeting the pivotal pathological processes of acute kidney injury (AKI) and parallelly monitoring the treatment process has emerged as an intriguing strategy for the timely tailored treatment of AKI, especially in the acute phase. Unfortunately, current clinical treatment approaches are restricted to supportive care, which shows limited efficiency. Herein, a multiantioxidant‐cooperative polydopamine‐based nanotheranostic platform (mc‐PDATP) is reported to achieve imaging‐assisted time‐sensitive therapy of AKI. Benefiting from the decoration of atomic Cu, mc‐PDATP comprehensively mimics the complicated antioxidant defense system as in natural environment, thus displaying improved catalytic activity to multiple toxic reactive oxygen species (ROS). Consequently, both in vitro and in vivo experiments confirm mc‐PDATP can efficiently protect the kidney from ROS attack and rescue the kidney function via targeting the inflammatory network of AKI. In addition, the coordinated atomic Gd contributes to a desired magnetic resonance (MR) T1‐weighted contrast effect of mc‐PDATP, which can be used to construct the sensitive MR histogram imaging signatures for pinpointing treatment effects in a timely manner. The study represents an innovative strategy for anti‐AKI therapy, which will facilitate the development of next‐generation theranostic nano‐antioxidants.
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