Phenolic components from the fruits of Solanum xanthocarpum with anti-inflammatory activity

AbstractAbstractTwo new compounds (1 and 2), along with thirty-one known compounds (3-33) were isolated from the fruits of Solanum xanthocarpum. The structure of isolates was elucidated by analysis of spectroscopic data and the physicochemical methods. Meanwhile, the anti-inflammatory activity of isolates was determined using LPS-induced RAW 264.7 cells. The results of anti-inflammatory assays indicated that most isolated compounds (3, 4, 6, 8-14, 17-20, and 30) possessed significant nitric oxide (NO) production inhibition in lipopolysaccharide (LPS)-induced RAW 264.7 cells with IC50 values ranging from 14.33 to 48.55 μM.GRAPHICAL ABSTRACTKeywords: PhenolicSolanum xanthocarpumAnti-inflammatory Disclosure statementNo potential conflict of interest was reported by the authors.Additional informationFundingThis work was financially supported by the key research and development projects of Heilongjiang province (GA21D008) and the Heilongjiang Touyan Innovation Team Program.