哈卡特
海藻酸钙
化学
体内
钙
自愈水凝胶
体外
锌
生物高聚物
核化学
聚合物
生物化学
高分子化学
有机化学
生物
生物技术
作者
Alba Cano-Vicent,Alberto Tuñón-Molina,Hamid A. Bakshi,Roser Sabater i Serra,Iman M. Alfagih,Murtaza M. Tambuwala,Ãngel Serrano‐Aroca
出处
期刊:ACS omega
[American Chemical Society]
日期:2023-06-28
卷期号:8 (27): 24396-24405
被引量:2
标识
DOI:10.1021/acsomega.3c01935
摘要
Alginate is a highly promising biopolymer due to its non-toxic and biodegradable properties. Alginate hydrogels are often fabricated by cross-linking sodium alginate with calcium cations and can be engineered with highly desirable enhanced physical and biological properties for biomedical applications. This study reports on the anticancer, antiviral, antibacterial, in vitro, and in vivo toxicity, water absorption, and compound release properties of an alginate hydrogel crosslinked with calcium and different amounts of zinc cations. The results showed that the calcium alginate hydrogel film crosslinked with the highest amount of zinc showed similar water sorption properties to those of calcium alginate and released a suitable amount of zinc to provide anticancer activity against melanoma and colon cancer cells and has antibacterial properties against methicillin-resistant Staphylococcus epidermidis and antiviral activity against enveloped and non-enveloped viruses. This film is non-toxic in both in vitro in keratinocyte HaCaT cells and in vivo in the Caenorhabditis elegans model, which renders it especially promising for biomedical applications.
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