Improved Factor Combination for In Vivo Reprogramming of Cardiac Myofibroblast to Cardiomyocyte-Like Cell With Dual Recombinase Tracing

HomeCirculationVol. 148, No. 21Improved Factor Combination for In Vivo Reprogramming of Cardiac Myofibroblast to Cardiomyocyte-Like Cell With Dual Recombinase Tracing No AccessResearch ArticleRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessResearch ArticleRequest AccessFull TextImproved Factor Combination for In Vivo Reprogramming of Cardiac Myofibroblast to Cardiomyocyte-Like Cell With Dual Recombinase Tracing Jingdong Wu, Hong Zhao, Yanmeng Tao, Chunyan Yang, Yang Yang, Bin Zhou and Yang Zhao Jingdong WuJingdong Wu https://orcid.org/0000-0002-5536-7438 State Key Laboratory of Natural and Biomimetic Drugs, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Center for Life Sciences, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, China (J.W., H.Z., Y.T., C.Y., Y.Y., Y.Z.). Search for more papers by this author , Hong ZhaoHong Zhao State Key Laboratory of Natural and Biomimetic Drugs, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Center for Life Sciences, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, China (J.W., H.Z., Y.T., C.Y., Y.Y., Y.Z.). Search for more papers by this author , Yanmeng TaoYanmeng Tao State Key Laboratory of Natural and Biomimetic Drugs, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Center for Life Sciences, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, China (J.W., H.Z., Y.T., C.Y., Y.Y., Y.Z.). Search for more papers by this author , Chunyan YangChunyan Yang https://orcid.org/0000-0003-0436-7128 State Key Laboratory of Natural and Biomimetic Drugs, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Center for Life Sciences, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, China (J.W., H.Z., Y.T., C.Y., Y.Y., Y.Z.). Search for more papers by this author , Yang YangYang Yang State Key Laboratory of Natural and Biomimetic Drugs, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Center for Life Sciences, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, China (J.W., H.Z., Y.T., C.Y., Y.Y., Y.Z.). Search for more papers by this author , Bin ZhouBin Zhou Correspondence to: Bin Zhou, MD, PhD, 320 Yueyang Rd, Shanghai, 200031, China, Email E-mail Address: [email protected] https://orcid.org/0000-0001-5278-5522 New Cornerstone Science Laboratory, State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China (B.Z.). Search for more papers by this author and Yang ZhaoYang Zhao Yang Zhao, PhD, No 5 Yi He Yuan Rd, Haidian District, Beijing 100871, China, Email E-mail Address: [email protected] https://orcid.org/0000-0002-0856-2724 State Key Laboratory of Natural and Biomimetic Drugs, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Center for Life Sciences, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, China (J.W., H.Z., Y.T., C.Y., Y.Y., Y.Z.). Search for more papers by this author Originally published20 Nov 2023https://doi.org/10.1161/CIRCULATIONAHA.122.062810Circulation. 2023;148:1728–1731FootnotesFor Sources of Funding and Disclosures, see page 1731.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Bin Zhou, MD, PhD, 320 Yueyang Rd, Shanghai, 200031, China, Email zhoubin@sibs.ac.cnYang Zhao, PhD, No 5 Yi He Yuan Rd, Haidian District, Beijing 100871, China, Email yangzhao@pku.edu.cnREFERENCES1. Garry GA, Bassel-Duby R, Olson EN. Direct reprogramming as a route to cardiac repair.Semin Cell Dev Biol. 2022; 122:3–13. doi: 10.1016/j.semcdb.2021.05.019CrossrefMedlineGoogle Scholar2. Zhao H, Zhang Y, Xu XC, Sun QS, Yang CY, Wang H, Yang JB, Yang Y, Yang XC, Liu Y, et al. Sall4 and MyoCD empower direct cardiac reprogramming from adult cardiac fibroblasts after injury.Front Cell Dev Biol. 2021; 9:608367. doi: 10.3389/fcell.2021.608367CrossrefMedlineGoogle Scholar3. Kanisicak O, Khalil H, Ivey MJ, Karch J, Maliken BD, Correll RN, Brody MJ, Lin SCJ, Aronow BJ, Tallquist MD, et al. Genetic lineage tracing defines myofibroblast origin and function in the injured heart.Nat Commun. 2016; 7:12260. doi: 10.1038/ncomms12260CrossrefMedlineGoogle Scholar4. Li Y, He LJ, Huang XZ, Bhaloo SI, Zhao H, Zhang SH, Pu WJ, Tian XY, Li Y, Liu QZ, et al. Genetic lineage tracing of nonmyocyte population by dual recombinases.Circulation. 2018; 138:793–805. doi: 10.1161/CIRCULATIONAHA.118.034250LinkGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. 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