化学
立体选择性
杂原子
产量(工程)
催化作用
硅烯醇醚
烯醇
药物化学
四级碳
戒指(化学)
乙醚
立体化学
硅烷化
有机化学
对映选择合成
材料科学
冶金
作者
Hideo Setsumasa,Kosuke Imai,Ikumi Kobayashi,Masahisa Nakada
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-10-30
卷期号:25 (44): 7953-7957
被引量:1
标识
DOI:10.1021/acs.orglett.3c02233
摘要
The Pd-catalyzed stereoselective construction of decalins with one-carbon units bearing heteroatoms at the ring junction is described. The Pd-catalyzed cyclization of silyl enol ether resulted in exclusive formation of the cis isomer (89%, >100/1 cis/trans). On the contrary, Pd-catalyzed carboiodination and carboborylation (with oxidative workup) provided products in 56% yield (1/>100 cis/trans) and 69% yield (1/11 cis/trans), respectively.
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