光动力疗法
鲁米诺
生物安全
纳米载体
化学发光
激光器
辐照
癌细胞
体内
纳米技术
介孔二氧化硅
化学
纳米颗粒
癌症
材料科学
癌症研究
医学
介孔材料
生物
病理
内科学
光学
生物化学
催化作用
物理
生物技术
有机化学
核物理学
作者
Wei Lin,Yiping Tan,Huaiyin Zhang,Pengyue Guo,Dongzhi Yang
标识
DOI:10.1016/j.pdpdt.2023.103756
摘要
Photodynamic therapy is a tumor treatment strategy. However, most of the photodynamic therapies rely on laser irradiation triggering, which limits their application in deep tissues. This study designed a self-luminescent nano system, hybrid protein oxygen nanocarrier coated graphene quantum dots (GQDs@HPOC) and mesoporous silica nanoparticles coated Luminol (L@MSNs), which self-assembled into GQDs@HPOC/L@MSNs without laser irradiation. The system utilized the weak acidic environment of tumors to trigger the release of Luminol and the chemiluminescence was catalyzed by HPOC. Next CRET occurred between Luminol and GQDs, producing 1O2, which could generate photodynamic damage to cervical cancer cells without the need for external laser irradiation. The system achieved the peak uptake in primary cervical cancer cells in 3 h, and had good biosafety before self-assembly. The system could significantly kill cells at a concentration of 16 μg/ml. The system will be further applied in in vivo experiments to investigate its therapeutic ability, providing a new strategy for the clinical treatment of cervical cancer.
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