医学
内科学
担心
癌症
生活质量(医疗保健)
焦虑
结直肠癌
萧条(经济学)
乳腺癌
化疗
肿瘤科
精神科
护理部
经济
宏观经济学
作者
Luís Carlos Lopes-Júnior,Karolini Zuqui Nunes,Raphael Manhães Pessanha,Luiz Claudio Barreto Silva Neto,Kátia Cirlene Gomes Viana,Jacques Grassi,Wesley Rocha Grippa,Raul Silva,Júlia Anhoque Cavalcanti Marcarini,Kátia N. Gomes,A. B. Lopes
标识
DOI:10.1016/j.annonc.2023.09.1659
摘要
Patients with cancer chemotherapy may have different cancer symptom clusters (CSC) that negatively impact their quality of life (QoL). These symptoms can sometimes arise from the disease itself or as a result of their cancer treatment. Cross-sectional observational study conducted at Hospital Santa Rita de Cássia, a reference in oncology treatment in the state of Espírito Santo, Brazil. We included a) patients of both sexes and >18 y.o.; b) anatomopathological diagnosis of malignant neoplasm in stage I-III; c) patients (only new cases) undergoing outpatient chemotherapy. The instruments for data collection were: 1) Sociodemographic and clinical instrument; 2) Memorial Symptom Assessment Scale (MSAS) to identify the CSC and 3) The EQ-5D-3L to assess QoL; 4) Nutritional Risk Screening. Each patient donated two blood samples for measurement of biomarkers (troponin I and C-reactive protein). Descriptive and bivariate statistical analyzes were conducted using SPSS v.28.0. Thirty-eight participants with a mean age of 56.09 y.o. diagnosed with malignant neoplasm were included. Most patients had a diagnosis of breast cancer (n=21; 55.26%), followed by the diagnosis of colorectal cancer (n=7; 18.42%). Most patients was into staging II (n=18; 47.37%). We observed a mean QoL score of 74, with the most affected domain being anxiety/depression (n=28; 73.68%). The most prevalent CSC were, worry (n=25; 65%), followed by pain (n=19; 50%). Three clusters were identified: 1-(difficulty for sleeping-sadness-worry); 2-(fatigue-nervousness-dry mouth) and 3-(pain-nausea-irritable-difficulty concentrating). Regarding nutritional status by we identified that most patients were classified as “normal”(n=22; 55.89%), followed by slightly altered (n=9), only one patient had serius nutritional status. Troponin I correlated with age (Rhos=0.31; p=0.033) and gender (Rhos= -0.48; p=0.02). C-relative protein showed a moderate and direct correlation with weight (Rhos=0.48; p=0.001) and waist circumference (Rhos=0.48; p=0.001). Adequate attention to CSC should be the basis for the accurate planning of effective interventions to manage the symptoms experienced by cancer patients.
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