病理学
淋巴结
病理
DNA测序
医学
生物
癌症研究
基因
疾病
遗传学
作者
Christopher J. Schwartz,Gregor Krings,Yunn‐Yi Chen
摘要
A malignant neoplasm with spindle cell and chondroid differentiation in the breast, metastatic to lymph node. In this context, a metaplastic carcinoma is typically favored given the exceptional nature of lymph node metastases in malignant phyllodes tumors (MPT). However, we demonstrate pathognomonic hotspot mutations in MED12 and the promoter of the TERT gene by targeted next-generation DNA sequencing, supporting a diagnosis of MPT.
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