医学
尿酸
超重
糖尿病
动脉硬化
内科学
2型糖尿病
体质指数
肥胖
脉冲波速
血压
前瞻性队列研究
内分泌学
作者
Andrew M. South,Joseph Rigdon,Saroja Voruganti,Jeanette M. Stafford,Dana Dabelea,Santica M. Marcovina,Amy K. Mottl,Cate Pihoker,Elaine M. Urbina,Elizabeth T. Jensen
标识
DOI:10.1210/clinem/dgad534
摘要
Uric acid's role in cardiovascular health in youth with type 1 diabetes is unknown.Investigate if higher uric acid is associated with increased blood pressure (BP) and arterial stiffness over time in adolescents and young adults with type 1 diabetes and if overweight/obesity modifies this relationship.Longitudinal analysis of data from adolescents and young adults with type 1 diabetes from two visits (mean follow up 4.6 years) in the SEARCH for Diabetes in Youth multicenter prospective cohort study from 2007-2018. Our exposure was uric acid at the first visit and our outcome measures were the change in BP, pulse wave velocity (PWV), and augmentation index between visits. We used multivariable linear mixed effects models and assessed for effect modification by overweight/obesity.Of 1,744 participants, mean age was 17.6 years, 49.4% were female, 75.9% non-Hispanic White, and 45.4% had a follow-up visit. Mean uric acid was 3.7 mg/dl (SD 1.0). Uric acid was not associated with increased BP, PWV-trunk, or augmentation index over time. Uric acid was marginally associated with PWV-upper extremity (β 0.02 m/s/year, 95% CI 0.002 to 0.04). The magnitude of this association did not differ by overweight/obesity status.Among adolescents and young adults with type 1 diabetes, uric acid was not consistently associated with increased BP or arterial stiffness over time. These results support findings from clinical trials in older adults with diabetes showing that lowering uric acid levels does not improve cardiovascular outcomes.
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