微塑料
炎症性肠病
环境卫生
疾病
炎症性肠病
污染物
微生物群
医学
环境污染
生物
生物信息学
环境保护
病理
生态学
环境科学
作者
Jiali Ji,Xinyue Wu,Xi Li,Ya Zhu
标识
DOI:10.1016/j.envres.2023.115974
摘要
The incidence of inflammatory bowel disease (IBD) has been increasing in recent years, particularly in newly industrialized nations. Environmental factors have been identified as playing a crucial role in IBD pathogenesis. Microplastics (MPs), a novel class of environmental pollutants, are a significant global pollution concern. MPs are found in almost all aquatic environments. MPs in the environment may pose health risks, specifically concerning the intestinal system, due to prolonged exposure through the consumption of aquatic foods and drinking water. In this review, we aimed to provide a comprehensive overview of the current knowledge on the impact of MPs in water resources on the occurrence and progression of IBD. Our systematic analysis of in vitro and in vivo studies found that MPs induce intestinal barrier dysfunction, imbalance in the intestinal microbiome, and metabolic abnormalities, ultimately leading to IBD. In addition, MP exposure causes greater harm to individuals with preexisting gastrointestinal disorders than those without them. Our analysis of this literature review highlights the need for further research to improve the understanding of the complex relationship between MP exposure and IBD.
科研通智能强力驱动
Strongly Powered by AbleSci AI