Role of Genetics in the Age-Related Testosterone Decline in Men - A UK Biobank Study.

生命银行 睾酮(贴片) 内科学 内分泌学 医学 生物 生理学 老年学 遗传学 人口学 社会学
作者
Lynn Ogoniak,Sarah Sandmann,Julian Varghese,Michael J. Ziller,Nina Neuhaus,Alexander S. Busch
出处
期刊:PubMed
标识
DOI:10.1093/ejendo/lvaf143
摘要

Age-related decline in circulating testosterone levels in men varies significantly and is often linked to comorbidities such as type 2 diabetes, and cardiovascular disease (CVD). While the genetic basis of testosterone levels is well-studied, the role of genetics in age-related testosterone decline remains unclear. This study aims to investigate the genetic contribution to age-related testosterone decline in men and its association with comorbidities. A longitudinal, population-based study in 6,354 men including consecutive testosterone (T), bioavailable testosterone (BAT), and sex hormone-binding globulin (SHBG) measurements. We assessed the association of longitudinal serum biomarker changes with changes in disease prevalences and a polygenic score (PGS) for BAT developed in 183,909 UK Biobank participants. In the follow-up cohort (mean age: 58.2 years; mean follow-up: 4.3 years), baseline levels of BAT, T, and SHBG were each negatively associated with their respective relative changes at follow-up (all p<0.001). A PGS for BAT, strongly associated with baseline levels (p=2.2x10-16, R²=0.16), was not associated with BAT decline over time. Genome-wide analysis of BAT change identified no significant genetic loci. Instead, the BAT decline was associated with prevalence of several comorbidities including cancers and CVD (p=0.007 and 0.012, respectively). Non-genetic factors are strongly associated with age-related BAT decline, whereas genetic predisposition may have a limited role. However, this does not rule out a potential genetic contribution. Our findings offer insight into the relationship between comorbidities and hormonal changes, supporting further research into their roles in testosterone decline and related health risks in aging men.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
英姑应助qiuqiu采纳,获得10
1秒前
泛泛之交发布了新的文献求助10
1秒前
1秒前
myfdll完成签到,获得积分20
2秒前
K. G.完成签到,获得积分10
2秒前
3秒前
宋宋宋2发布了新的文献求助10
3秒前
喵喵完成签到,获得积分10
3秒前
3秒前
wangshuhong发布了新的文献求助10
4秒前
yar应助zuifeng采纳,获得10
5秒前
myfdll发布了新的文献求助10
6秒前
6秒前
义气的碧玉完成签到,获得积分10
6秒前
123发布了新的文献求助10
7秒前
25689发布了新的文献求助10
7秒前
8秒前
七田皿发布了新的文献求助10
9秒前
loststarts应助老牛马采纳,获得10
9秒前
9秒前
ff完成签到,获得积分10
9秒前
9秒前
10秒前
什米完成签到,获得积分10
10秒前
10秒前
ding应助健忘惜海采纳,获得10
11秒前
cx发布了新的文献求助10
11秒前
超级盼海发布了新的文献求助10
12秒前
ED应助义气的碧玉采纳,获得10
12秒前
平淡的百招完成签到,获得积分10
12秒前
共享精神应助科研通管家采纳,获得10
12秒前
牛山山完成签到,获得积分10
12秒前
超帅连虎应助科研通管家采纳,获得10
12秒前
桐桐应助科研通管家采纳,获得10
12秒前
Singularity应助科研通管家采纳,获得10
12秒前
12秒前
12秒前
领导范儿应助科研通管家采纳,获得10
12秒前
13秒前
13秒前
高分求助中
【重要!!请各位用户详细阅读此贴】科研通的精品贴汇总(请勿应助) 10000
植物基因组学(第二版) 1000
Plutonium Handbook 1000
Three plays : drama 1000
International Code of Nomenclature for algae, fungi, and plants (Madrid Code) (Regnum Vegetabile) 1000
Psychology Applied to Teaching 14th Edition 600
Robot-supported joining of reinforcement textiles with one-sided sewing heads 600
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4095198
求助须知:如何正确求助?哪些是违规求助? 3633387
关于积分的说明 11516783
捐赠科研通 3344140
什么是DOI,文献DOI怎么找? 1837942
邀请新用户注册赠送积分活动 905421
科研通“疑难数据库(出版商)”最低求助积分说明 823191