异质性
线粒体DNA
遗传学
线粒体
生物
突变
基因
作者
Huihui Huang,Yi Wang,Zsuzsanna K. Zsengellér,Joshua Gorham,Vamsidhara Vemireddy,Amanda J. Clark,Hui Pan,Jonathan M. Dreyfuss,Vasantha Jotwani,Michael G. Shlipak,Mark J. Sarnak,Chirag R. Parikh,Heather Thiessen‐Philbrook,Ronit Katz,Sushrut S. Waikar,Nicole J. Lake,Monkol Lek,Wen Shi,Daniela Puiu,Yun Soo Hong
出处
期刊：Science
[American Association for the Advancement of Science]
日期：2025-09-04
卷期号：390 (6769): 164-172
被引量：6
标识
DOI：10.1126/science.adk7978
摘要
). Heteroplasmic mtDNA mutations may therefore reflect the cumulative effect of acute injuries to metabolically active cells, impairing major functions in a fashion amenable to nuclear-controlled purine biosynthesis.
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