Near-Infrared Light-Driven Efficient Tumor Elimination via Strong Oxidative Photogenerated Holes in Donor–Acceptor Supramolecular Porphyrin

Efficient photocatalytic tumor therapy relies on deep tissue penetration via near-infrared (NIR) light absorption and potent oxidative stress induced by efficient photogenerated hole (h⁺) migration. Herein, we report a supramolecular donor-acceptor (D-A) structure fabricated by integrating self-assembled tetra-(4-carboxyphenyl) porphyrin (SA-TCPP) with amino-functionalized graphene quantum dots (GQDs-NH₂). The D-A configuration significantly narrowed the band gap for extended NIR absorption and amplified the interfacial electric field 6.2 times. This facilitated efficient h⁺ migration with a 5.3-fold enhancement, generating highly oxidation holes. Under 700 nm irradiation, this system induced potent oxidative cell apoptosis, leading to 100% tumor elimination in vivo. This study presents a dual-promotion strategy involving NIR responsiveness and charge migration, advancing the efficiency of photocatalytic cancer therapy.