免疫检查点
N6-甲基腺苷
癌症
甲基化
癌症研究
免疫疗法
生物标志物
封锁
免疫系统
癌症免疫疗法
RNA甲基化
生物
肿瘤科
计算生物学
医学
内科学
免疫学
基因
受体
遗传学
甲基转移酶
作者
Wei Yin,Zhimin Huo,Jiawei Zuo,Haixiao Wang,Caifeng Bi,Lixin Zhou
出处
期刊:Aging
[Impact Journals, LLC]
日期:2023-12-29
标识
DOI:10.18632/aging.205341
摘要
Widely recognized as an essential epitranscriptomic modification, RNA N6-methyladenosine (m6A) is involved in both physiological and pathological processes. Here, we want to investigate m6A modificationâs potential roles in gastric cancer. Gastric cancer samples were selected from TCGA-STAD and GEO (GSE84426, GSE84433) datasets. Based on 18 regulators of m6A, m6A modification patterns were thoroughly evaluated in gastric cancer samples. Principal component analysis algorithms were used to construct the m6Ascore, using which, m6A modification features in tumor somatic mutations and immune checkpoint blockade therapy were analyzed. 34 gastric cancer samples were collected to verify the effectiveness of the m6Ascore. Here, we determined three different m6A modification patterns. m6Acluster-C modification pattern presented immune activation-associated enrichment pathways and have significant survival advantages. Then, in gastric cancer, m6Ascore could act as an independent prognostic biomarker. A significant survival benefit was exhibited in patients with high m6Ascore. Moreover, the modification signature of m6A uncovered in this study would help to predict immune checkpoint blockade therapyâs responses. In conclusion, our discoveries all pointed to the fact that modification patterns of m6A were linked to the TME. Moreover, evaluation of individual tumorâs m6A modification pattern will help to guide immunotherapy strategies that shows more therapeutic effects.
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