罗氟司特
最后
溃疡性结肠炎
银屑病
前药
医学
药理学
特发性肺纤维化
磷酸二酯酶
结肠炎
促炎细胞因子
磷酸二酯酶抑制剂
炎症
慢性阻塞性肺病
免疫学
化学
酶
内科学
银屑病性关节炎
疾病
生物化学
肺
作者
J Bernard,Christophe Mellon,Maxime Ranger,Bernard Cǒté,Michelle Jones
标识
DOI:10.1053/j.gastro.2023.11.035
摘要
Phosphodiesterase-4 (PDE4) is a key enzyme in cAMP hydrolysis and is involved in various inflammatory and fibrotic diseases, such as ulcerative colitis (UC). PDE4 inhibition elevates intracellular cAMP, downregulates inflammatory cytokines (e.g., TNFα), and reduces cell adhesion molecules, thereby preventing local infiltration of inflammatory cells. Several PDE4 inhibitors (e.g., roflumilast and apremilast) are approved for COPD and psoriasis, with others under development for diseases such as idiopathic pulmonary fibrosis (IPF).
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