法尼甾体X受体
胆汁酸
G蛋白偶联胆汁酸受体
生物
寄主(生物学)
肠道菌群
胆酸
新陈代谢
受体
生物化学
微生物学
核受体
基因
遗传学
转录因子
作者
Chang Liu,Meng‐Xuan Du,Le Xie,Wen-Zhao Wang,Baosong Chen,Chuyu Yun,Xuepeng Sun,Xi Luo,Yu Jiang,Kai Wang,Min-Zhi Jiang,Shushan Qiao,Min Sun,Baojuan Cui,Hao-Jie Huang,Sai Qu,Chang-Kun Li,Dalei Wu,Lushan Wang,Changtao Jiang,Hongwei Liu,Shuang‐Jiang Liu
出处
期刊:Nature microbiology
日期:2024-01-17
标识
DOI:10.1038/s41564-023-01570-0
摘要
A strong correlation between gut microbes and host health has been observed in numerous gut metagenomic cohort studies. However, the underlying mechanisms governing host-microbe interactions in the gut remain largely unknown. Here we report that the gut commensal Christensenella minuta modulates host metabolism by generating a previously undescribed class of secondary bile acids with 3-O-acylation substitution that inhibit the intestinal farnesoid X receptor. Administration of C. minuta alleviated features of metabolic disease in high fat diet-induced obese mice associated with a significant increase in these acylated bile acids, which we refer to as 3-O-acyl-cholic acids. Specific knockout of intestinal farnesoid X receptor in mice counteracted the beneficial effects observed in their wild-type counterparts. Finally, we showed that 3-O-acyl-CAs were prevalent in healthy humans but significantly depleted in patients with type 2 diabetes. Our findings indicate a role for C. minuta and acylated bile acids in metabolic diseases.
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