生物
胰腺癌
基因敲除
免疫疗法
癌症研究
癌症
生物标志物
肿瘤科
内科学
免疫系统
免疫学
细胞培养
医学
遗传学
生物化学
作者
Hui Deng,Hanming Yao,Shurui Zhou,Chong He,Yuzhou Huang,Yunlong Li,Hanwei Chen,Jianchang Shu
标识
DOI：10.1016/j.mcp.2023.101948
摘要
Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant gastrointestinal tumors worldwide with a dismal prognosis and high relapse rate. PDAC is considered a "cold cancer" for which immunotherapy is not effective. Therefore, to improve the prognosis for PDAC patients, it is urgent to explore the mechanism driving its insensitivity to immunotherapy.
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