急性呼吸窘迫综合征
两性离子
粘液
一氧化氮
炎症
地塞米松
支气管肺泡灌洗
医学
肺
免疫学
药理学
化学
生物
内科学
生态学
有机化学
分子
作者
Kyungtae Park,Sung-Won Jung,Hye-Jin Lee,Hyangsu Nam,Sungeun Heo,Yoogyeong Oh,C. Park,Jungbum Kim,Jae‐Jun Ahn,Jong Bum Lee,Patrick T.J. Hwang,Sangmin Lee,Wonhwa Lee,Jinkee Hong
标识
DOI:10.1016/j.mattod.2023.11.011
摘要
Among patients who suffer from lung-related disability, acute respiratory distress syndrome (ARDS) is one of the diseases with the significant mortality rate and the main cause is the interference in pulmonary drug delivery by accumulated bronchoalveolar lavage fluid (BALF) in the alveolar region. Here, a zwitterion-functionalized multi-drug nanocomplex (ZnC) capable of anti-mucociliary clearance was synthesized. Additionally, nitric oxide (NO) was functionalized with ZnC to fuel the mobility in the BALF through its role as a nanomotor as well as anti-inflammation. Subsequently, dexamethasone (Dex) was loaded and final product of anti-inflammatory mucus permeator (AIM) was introduced. By in situ tracking the AIM within the mucus-rich environment, the fueled mobility by NO and zwitterion was demonstrated. Notably, when AIM was inhaled by the in vivo ARDS model, there was an increase in the anti-inflammation effect due to the presence of ZnC as well as the synergy between NO and Dex, which recovered the pulmonary function of the model and increased survival rate.
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