Press‐to‐Seal Hydrogel Patches with Spatiotemporally Controllable Blood Repulsion for Acute Hemostasis and Enhanced Healing of Deep Incisive Wounds

Abstract Deep incisive wounds hemostasis and healing remain a significant challenge. Silicone oil (SO)‐mediated blood repulsion enables bioadhesion to seal; however, achieving stable SO encapsulation, its controllable release, and then strong bioadhesion poses significant challenges. Herein, press‐actuated silicone oil micro‐reservoirs are engineered and assemble into adhesive hydrogel matrix, yielding press‐to‐seal hydrogel patches with user‐initiated and press‐triggered SO release, and area‐controlled blood repulsion, and strong bioadhesion. Pressing the patch onto wet tissues to release SO, generating interfacial dehydration for tight hydrogel‐tissue anchoring. Concurrently, functional groups between the hydrogel and tissue form multivalent physical interactions to achieve the expected adhesive and sealing performance. In animal deep incisive wounds, the press‐to‐seal hydrogel patches exhibit better hemostatic and accelerated wound healing performance than that of commercial adhesives. Tandem mass tags‐labeled quantitative proteomics revealed that the press‐to‐seal hydrogel exerts targeted regulation on hemostatic, inflammatory, and tissue repair‐associated proteins, critically modulating their expression during wound healing. This work provides a novel idea for spatiotemporal control of SO release, blood repulsion, and adhesion performance of the adhesive materials.