Press‐to‐Seal Hydrogel Patches with Spatiotemporally Controllable Blood Repulsion for Acute Hemostasis and Enhanced Healing of Deep Incisive Wounds

Deep incisive wounds hemostasis and healing remain a significant challenge. Silicone oil (SO)-mediated blood repulsion enables bioadhesion to seal; however, achieving stable SO encapsulation, its controllable release, and then strong bioadhesion poses significant challenges. Herein, press-actuated silicone oil micro-reservoirs are engineered and assemble into adhesive hydrogel matrix, yielding press-to-seal hydrogel patches with user-initiated and press-triggered SO release, and area-controlled blood repulsion, and strong bioadhesion. Pressing the patch onto wet tissues to release SO, generating interfacial dehydration for tight hydrogel-tissue anchoring. Concurrently, functional groups between the hydrogel and tissue form multivalent physical interactions to achieve the expected adhesive and sealing performance. In animal deep incisive wounds, the press-to-seal hydrogel patches exhibit better hemostatic and accelerated wound healing performance than that of commercial adhesives. Tandem mass tags-labeled quantitative proteomics revealed that the press-to-seal hydrogel exerts targeted regulation on hemostatic, inflammatory, and tissue repair-associated proteins, critically modulating their expression during wound healing. This work provides a novel idea for spatiotemporal control of SO release, blood repulsion, and adhesion performance of the adhesive materials.