烯酮
化学
羰基化
环加成
重氮
沃尔夫重排
组合化学
有机化学
内酰胺
催化作用
一氧化碳
作者
Fathima Febin Koothradan,Arumugam Jayarani,Chinnappan Sivasankar
标识
DOI:10.1021/acs.joc.2c01484
摘要
Reporting an efficient method for the synthesis of β-lactams by the carbonylation of diazo compounds, using [Co2(CO)8] to corresponding ketenes, followed by [2 + 2] cycloaddition with imines. The newly developed strategy was successfully applied to electronically and structurally diverse substrates to produce the corresponding β-lactams under mild reaction conditions. Fourier transform infrared spectroscopy was employed to monitor ketene formation and the transformation of ketene into β-lactam. All the products were fully characterized by using various analytical and spectroscopic techniques.
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