壳聚糖
抗菌活性
银纳米粒子
表面等离子共振
核化学
化学
肉汤微量稀释
傅里叶变换红外光谱
最小抑制浓度
摩尔吸收率
纳米颗粒
细菌
材料科学
抗菌剂
纳米技术
化学工程
有机化学
生物
遗传学
物理
光学
工程类
作者
Е. К. Уродкова,O. Ya. Uryupina,Е. С. Жаворонок,Natalia E. Grammatikova,Т. В. Харитонова,I. N. Senchikhin
标识
DOI:10.1002/slct.202203609
摘要
Abstract The results of the testing of silver nanoparticles (AgNPs) antibacterial activity obtained in aqua solutions of high molecular chitosan and oligochitosans at near‐physiological pH values are demonstrated. Aggregative stable AgNPs were synthesized in solutions of chitosans of average molecular weight of 6, 12 and 311 kDa. Nanodispersions were characterized by UV‐Vis and FTIR, SEM and TEM. AgNPs formation was confirmed by the presence of the surface plasmon resonance peak at nearly 425 nm in the extinction spectrum and TEM. The average size of approximately 40–90 nm was determined by DLS, electron microscopy and UV‐Vis. Minimal inhibitory concentrations were determined by microdilution in the Mueller‐Hinton broth method. The AgNPs dispersions exhibit a significant antibacterial effect toward both Gram‐positive and Gram‐negative bacteria strain (MIC values are of 1–8 μg/ml). The effect is little dependent on polymer molecular weight. A two‐stage Staphylococcus aureus growth suppression effect was found for the first time.
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