α-Aminophosphonates Containing Sterically Hindered Phenolic and N-Heterocyclic Fragments as Potentional Antitumor Agents

Aliphatic amines containing N-heterocyclic fragments reacted with dialkyl [3,5-di-tert-butyl-4-oxo-2,5-cyclohexadienylidene)methyl] phosphonates to form 1,6-nucleophilic addition products. This approach was used to obtain α-aminophosphonates containing sterically hindered phenol and N-heterocyclic fragments in high yields. All the compounds were evaluated for their in vitro cytotoxicity with various cancer cell lines by MTT assay method. In the course of biological studies, it was found that the obtained compounds possess cytotoxic activity against some tumor cells.