再生(生物学)
组织修复
背景(考古学)
免疫系统
纤维化
生物
细胞生物学
功能(生物学)
免疫学
免疫耐受
癌症研究
医学
病理
古生物学
作者
Lucas F. Loffredo,Thomas Savage,Olivia R Ringham,Nicholas Arpaia
摘要
Regulatory T (Treg) cells are classically known for their critical immunosuppressive functions that support peripheral tolerance. More recent work has demonstrated that Treg cells produce pro-repair mediators independent of their immunosuppressive function, a process that is critical to repair and regeneration in response to numerous tissue insults. These factors act on resident parenchymal and structural cells to initiate repair in a tissue-specific context. This review examines interactions between Treg cells and tissue-resident non-immune cells—in the context of tissue repair, fibrosis, and cancer—and discusses areas for future exploration.
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