医学
副作用(计算机科学)
临床试验
生活质量(医疗保健)
肿瘤科
纤维化
放射治疗
内科学
重症监护医学
计算机科学
护理部
程序设计语言
作者
Moses Tam,Praveen Arany,Jolien Robijns,Rodrigo Nogueira de Vasconcelos,Patricia Corby,Kenneth Hu
出处
期刊:Photobiomodulation, photomedicine, and laser surgery
[Mary Ann Liebert]
日期:2020-06-01
卷期号:38 (6): 355-363
被引量:4
标识
DOI:10.1089/photob.2019.4766
摘要
Objective: We evaluated the role of photobiomodulation (PBM) in radiation fibrosis syndrome (RFS). Background: Radiation therapy (RT) is an important treatment utilized in over half of newly diagnosed cancers. Despite its benefits, patients treated with RT may experience acute and chronic significant side effects depending on both treatment- and patient-related factors. RFS is an important long-term side effect of RT, which can adversely impact patient's quality of life and organ function. With improved oncologic outcomes and survival for cancer patients after radiation, there is an unmet need to address long-term side effects of RT, particularly RFS. Results: Photobiomodulation (PBM) using low energy, nonionizing light primarily in the visible (especially red) or near-infrared spectrum has been demonstrated to decrease acute side effects of radiation in rigorously conducted phase III randomized studies; however, its potential benefit in ameliorating chronic radiation side effects, particularly RFS remains to be investigated. Conclusions: This review summarizes the in vitro data, preclinical animal studies and clinical reports, which showcase the potential benefits of PBM treatments in preventing and reversing RFS.
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