Advances in the application of anticoagulant drugs during the treatment of pulmonary hypertension

Pulmonary hypertension is a group of clinical syndrome characterized by increased pulmonary vascular resistance, its pathogenesis is complex and prognosis is poor.Studies have shown that situ thrombosis and blood coagulation dysfunction play an important role in the pathogenesis of pulmonary hypertension, both of them are weighted mechanisms of occurrence and development of pulmonary hypertension.However, the application of anticoagulant drugs in pulmonary hypertension has not been unified conclusion yet.In this article, we are going to expound pathological and physiological basis in application of anticoagulant drugs in pulmonary hypertension treatment, then we will review anticoagulant drugs currently in pulmonary hypertension application and the latest progress. Key words: Hypertension, pulmonary; Thrombus; Anticoagulation