Synthesis and characterization of Fe3O4@SiO2@MIL-100(Fe) nanocomposite: A nanocarrier for loading and release of celecoxib

Abstract In this paper, a magnetic and highly porous nanocarrier was synthesized via growing the MIL-100(Fe) on Fe3O4@SiO2 nanoparticles. The effect of several factors on celecoxib adsorption and its release behavior were investigated. The adsorption of celecoxib on Fe3O4@SiO2@MIL-100(Fe) NPs followed the Langmuir isotherm model, indicating the monolayer sorption of the drug molecules on the active sites of the nanocarrier. The adsorption process was completed in only 30 min, followed by the pseudo-second-order and intraparticle adsorption kinetic model. The release study at different pH showed that there is a controlled release at physiological pH (~7.4) while the release becomes burst at acidic pH. The result described by the Higuchi and the Korsmeyer-Peppas release kinetic models for neutral pH (i.e., 7.4) and acidic pH, respectively. The cytotoxicity of the as-synthesized nanocarrier was investigated using MTT assay. The developed nanocarrier showed high biocompatibility with normal NIH-3T3 cells. However, the release in the acidic environment of Hela cancer cells revealed the high potential of the developed nanocarrier for future In-vivo studies.