Superlubricated Microspheres: Ball‐Bearing‐Inspired Polyampholyte‐Modified Microspheres as Bio‐Lubricants Attenuate Osteoarthritis (Small 44/2020)

SmallVolume 16, Issue 44 2070238 Cover PictureFree Access Superlubricated Microspheres: Ball-Bearing-Inspired Polyampholyte-Modified Microspheres as Bio-Lubricants Attenuate Osteoarthritis (Small 44/2020) Jielai Yang, Jielai Yang Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. China Department of orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. ChinaSearch for more papers by this authorYing Han, Ying Han State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084 ChinaSearch for more papers by this authorJiawei Lin, Jiawei Lin Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. China Department of orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. ChinaSearch for more papers by this authorYuan Zhu, Yuan Zhu Department of orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. ChinaSearch for more papers by this authorFei Wang, Fei Wang Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. ChinaSearch for more papers by this authorLianfu Deng, Lianfu Deng Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. ChinaSearch for more papers by this authorHongyu Zhang, Hongyu Zhang State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084 ChinaSearch for more papers by this authorXiangyang Xu, Xiangyang Xu Department of orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. ChinaSearch for more papers by this authorWenguo Cui, Wenguo Cui Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. ChinaSearch for more papers by this author Jielai Yang, Jielai Yang Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. China Department of orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. ChinaSearch for more papers by this authorYing Han, Ying Han State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084 ChinaSearch for more papers by this authorJiawei Lin, Jiawei Lin Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. China Department of orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. ChinaSearch for more papers by this authorYuan Zhu, Yuan Zhu Department of orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. ChinaSearch for more papers by this authorFei Wang, Fei Wang Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. ChinaSearch for more papers by this authorLianfu Deng, Lianfu Deng Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. ChinaSearch for more papers by this authorHongyu Zhang, Hongyu Zhang State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084 ChinaSearch for more papers by this authorXiangyang Xu, Xiangyang Xu Department of orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. ChinaSearch for more papers by this authorWenguo Cui, Wenguo Cui Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025 P. R. ChinaSearch for more papers by this author First published: 05 November 2020 https://doi.org/10.1002/smll.202070238AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Inspired by the unique structure and lubrication mechanism of ball bearing, monodisperse, size-uniform hydrogel spheres are fabricated by Hongyu Zhang, Xiangyang Xu, Wenguo Cui, and co-workers in article number 2004519 using microfluidic technology, and subsequently modified with pSBMA to form superlubricated hydrogel microspheres using a one-step bionic grafting approach. The superlubricated hydrogel microspheres, with properties of enhanced lubrication and sustained drug release, are used for intra-articular treatment of osteoarthritis. Volume16, Issue44November 5, 20202070238 RelatedInformation