祖细胞
形态发生
诱导多能干细胞
细胞生物学
干细胞
生物
再生(生物学)
胃肠道
食管
病理
骨形态发生蛋白
免疫学
胚胎干细胞
医学
解剖
遗传学
基因
生物化学
作者
Yongchun Zhang,Jianwen Que
出处
期刊:Annual Review of Physiology
[Annual Reviews]
日期:2020-02-10
卷期号:82 (1): 251-273
被引量:39
标识
DOI:10.1146/annurev-physiol-021119-034500
摘要
The bone morphogenetic protein (BMP) pathway is essential for the morphogenesis of multiple organs in the digestive system. Abnormal BMP signaling has also been associated with disease initiation and progression in the gastrointestinal (GI) tract and associated organs. Recent studies using animal models, tissue organoids, and human pluripotent stem cells have significantly expanded our understanding of the roles played by BMPs in the development and homeostasis of GI organs. It is clear that BMP signaling regulates GI function and disease progression that involve stem/progenitor cells and inflammation in a tissue-specific manner. In this review we discuss these new findings with a focus on the esophagus, stomach, and intestine.
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