多囊卵巢
卵泡发生
病态的
生物
小RNA
卵巢早衰
生物信息学
生殖医学
卵巢
医学
内科学
内分泌学
基因
遗传学
怀孕
胚胎发生
胰岛素抵抗
胰岛素
作者
Jiajie Tu,Yu Chen,Zhe Li,Huan Yang,He Chen,Zhiying Yu
标识
DOI:10.1186/s13048-020-00663-2
摘要
Abstract Granulosa cells (GCs) are somatic cells surrounding oocytes within follicles and are essential for folliculogenesis. Pathological changes in GCs are found in several ovarian disorders. Recent reports have indicated that long non-coding RNAs (lncRNAs), which modulate gene expression via multiple mechanisms, are key regulators of the normal development of GCs, follicles, and ovaries. In addition, accumulating evidence has suggested that lncRNAs can be utilized as biomarkers for the diagnosis and prognosis of GC-related diseases, such as polycystic ovary syndrome (PCOS) and premature ovarian insufficiency (POI). Therefore, lncRNAs not only play a role in GCs that are involved in normal folliculogenesis, but they may also be considered as potential candidate biomarkers and therapeutic targets in GCs under pathological conditions. In the future, a detailed investigation of the in vivo delivery or targeting of lncRNAs and large-cohort-validation of the clinical applicability of lncRNAs is required.
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