达托霉素
抗生素
青霉素
微生物学
生物
细菌
医学
金黄色葡萄球菌
万古霉素
遗传学
作者
Xiaoqian Wu,Julian G. Hurdle
出处
期刊:Antibiotics
[MDPI AG]
日期:2013-10-04
卷期号:: 183-216
标识
DOI:10.1002/9783527659685.ch8
摘要
Since the discovery of penicillin, the ability to treat dormant bacterial infections with most chemotherapeutic agents has always been an enormous challenge. In these infections, bacteria are metabolically inactive and are often not killed by bactericidal agents or require protracted treatments. Within the past decade, the clinical advent of daptomycin, lipoglycopeptides, and other molecules with membrane-active properties have shown that targeting the membrane could be an approach to treat dormant infections. This emerging paradigm is the focus of this chapter, where we describe examples of these agents, their modes of actions and challenges that affect their clinical development.
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