PSEN1型
早老素
内嗅皮质
海马结构
神经科学
阿尔茨海默病
生物
痴呆
淀粉样前体蛋白
医学
疾病
内科学
作者
Roger Delabio,Lucas Trevizani Rasmussen,Igor Mizumoto,Gustavo-Arruda Viani,Elizabeth Chen,Joào Villares,Isabela-Bazzo Costa,Gustavo Turecki,Sandra Linde,Marı́lia de Arruda Cardoso Smith,Spencer L. M. Payão
摘要
Presenilin 1 (PSEN1) and presenilin 2 (PSEN2) genes encode the major component of y-secretase, which is responsible for sequential proteolytic cleavages of amyloid precursor proteins and the subsequent formation of amyloid-β peptides. 150 RNA samples from the entorhinal cortex, auditory cortex and hippocampal regions of individuals with Alzheimer's disease (AD) and controls elderly subjects were analyzed with using real-time rtPCR. There were no differences between groups for PSEN1 expression. PSEN2 was significantly downregulated in the auditory cortex of AD patients when compared to controls and when compared to other brain regions of the patients. Alteration in PSEN2 expression may be a risk factor for AD.
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